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The sufficient concentration oxidation of polyunsaturated fatty acids (PUFAs) and phospholipids, the dysregulation of iron metabolism, and the loss of antioxidant defense system execute the ferroptosis [11] and the mechanism of ferroptosis involves a complicated interplay between multiple cellular pathways, including iron metabolism, lipid metabolism, and antioxidant defense mechanisms [12]

2.2.1 Cardiovascular system Cardiovascular safety is one of the primary concerns for T2DM patients

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May 22 2019;10(5):2888-2893

Turkova, A