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10.1371/journal.pone.0148042 [DOI] [PMC free article] [PubMed] [Google Scholar] 237.Liu M, Ma J, Xu J, Huangfu W, Zhang Y, Ali Q, et al

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Notably, studies have reported that DSIP-mediated analgesia occurs without the tolerance development typically seen with exogenous opioid compounds, suggesting a fundamentally different mechanism of interaction with the opioid system

Therefore, specific immunotherapies that target cytokines that activate specific immune cell subpopulations (Rider et al., 2016

doi: 10.1172/JCI83083