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Pioglitazone and bladder cancer risk: a systematic review and meta-analysis

Carey and Pickarts ultrasound study found an average increase in collagen density of ~28% at 12 weeks, with top responders reaching 51%

Animal studies have demonstrated effects on gastric function, gut-brain signaling, and inflammatory pathways that overlap with some GLP-1 mechanisms

Require nutrient support during calorie restriction or elimination diets

Suggested table of clinical case studies (to include in article): columns for patient phenotype (age, BMI, diagnosis), peptide used (dose, duration), metabolic outcomes (weight change, HOMA-IR), reproductive outcomes (ovulation, oocyte yield, pregnancy), adverse events, and follow-up duration, such as PCOS, obesity-associated anovulation, poor ovarian response, and metabolic syndrome