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Remarkably, LC increased NOX4 expression and reinstated the release of its product, hydrogen peroxide, indicating that NOX4 may defend against leptin-induced kidney injury (Blanca et al., 2016)

Including weight loss [14], heart disease [15], kidney disease [13] and cerebral disease [16, 17]

Albu S, Chirtes F

Carnitine depletion has several adverse effects

Except for UDCA and LCA, primarily eliminated in feces, all conjugated and unconjugated bile acids in the lumen can be reabsorbed (95%) and returned to the liver (90)

The increased metabolic burden subsequently accelerates cellular damage and dysfunction, resulting in inflammatory responses among immune cells and stromal cells (Fig