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At the same time, transcription factors such as c-MYC can also control the inflammatory response of macrophages and polarize them towards the M2 phenotype whereas c-MYC inhibitors can block this effect (50)

It can increase erythropoiesis under certain conditions
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Medications, existing liver or kidney disease, and concurrent supplement use can alter glutathione metabolism and efficacy

The denaturating effect of these solutions limits their usage

While NMN remains safe, one company is considering developing it as a prescription drug
