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Preclinical safety data In mouse studies, 5-amino-1mq was well-tolerated even at doses several times higher than those producing metabolic effects

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In a human hair follicle organ culture model, AHK-Cu demonstrated three key effects at concentrations of 10^-12 to 10^-9 M (extremely low doses) (Pyo et al., Arch Pharm Res, 2007)

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Shorb knew that the same liver extract was used to treat pernicious anemia (her father-in-law had died from the disease), and concluded that LLD could be developed as an assay method to identify the active compound
