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Wood says, because GLP-1s suppress appetite and slow gastric emptying, patients may unintentionally drink less throughout the day

Limit items high in added sugar, saturated fat, or sodium, which can increase gastrointestinal discomfort and make weight loss harder to sustain, Harris-Pincus says

It's administered as a once-weekly injection under the skin, typically in the stomach, thigh, or upper arm

The FDA has not approved any compounded version, and the raw peptide being sold by some online pharmacies has not been tested for human use at clinical doses

Metformin is also "the most common medication prescribed off-label for weight loss," Weintraub said, though most people who take it will only lose a modest amount of weight, perhaps around 5 to 10 pounds

Bile Acid Diarrhea in Adults and Adolescents