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References Ogden, S

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In NHPs receiving SC infusions of 0.5 mg/kg/24 h of setmelanotide, the efficacious dose for DIO NHPs determined by Kievit et al., a C max of approximately 150 ng/mL was reached within the first two hours and persisted for the duration of the treatment, resulting in an AUC 24 h of 3814 ng x h/mL ( max of only approximately 5 ng/mL that was maintained for the entire 28-day study, 30-fold lower than in NHPs ( max of 27.5 ng/mL with an AUC 24 h of 347 ng x h/mL, 10-fold lower than those observed in NHPs ( Although it appears that subtherapeutic doses of setmelanotide were used in clinical trials, higher doses of setmelanotide would require careful observation of cardiac side effects

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