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Briefly, protein aggregates should bind to the HSP70-HSP40 complex and p97, a powerful ATPase, at the same time and then be recognized by TAX1BP1 and routed into aggrephagosomes ( Chaperone-associated selective autophagy Chaperone-assisted selective autophagy (CASA) mediates lysosomal degradation of proteins delivered by a complex comprising HSC70, BAG3, and HSPB8

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Quickstart Highlights Cagrilintide is a longacting acylated analogue of the pancreatic hormone amylin, designed for onceweekly subcutaneous administration [1]

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