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Finally, the protonated glutamate residue donates a hydrogen to the amine of the -linked peptide, releasing an amino acid with a free amino group (Figure 3) ( FIGURE 3 The ChaC-like family proteins, including CHAC1, preferentially degrade reduced glutathione but can also break down other -glutamyl amino acids ( Although CHAC2 enzymes in Leishmania major were shown to degrade only reduced and not oxidized glutathione, this specificity has yet to be confirmed for CHAC1 ( CHAC2 is both evolutionarily older and structurally distinct from CHAC1

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In glucose depleted environment, human pancreas cells upregulate the expression of the TfR [44]

Aykin-Burns N, Ahmad IM, Zhu Y, Oberley LW, Spitz DR

Trends Plant Sci 26:7082 Zhu B, Zheng S, Fan W, Zhang M, Xia Z, Chen X, Zhao A (2022) Ectopic overexpression of mulberry MnT5H2 enhances melatonin production and salt tolerance in tobacco