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[20] Musculoskeletal discomfort (myalgia, limb pain) usually surfaces 12-24 hours after dosing, peaks at 48 hours, and resolves within 72 hours

For semaglutide, this means refrigeration until its time to use

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Some people can build muscle while using GLP-1 medication, especially beginners or people returning to training

A rapid increase in dose, even following the standard titration schedule, can sometimes lead to an accumulation of effects, resulting in severe discomfort weeks later

It can also help to work with a registered dietitian
