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doi:10.1080/09546634.2017.1373735

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Kidney Concerns at High Doses In the 2-year MS trial using 1,200 mg/day, a greater number of participants in the alpha-lipoic acid group experienced protein in the urine (proteinuria) and poor kidney function compared to placebo [19]

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To address limitations of natural exosomesincluding low drug efficacy and poor targetingengineering modification strategies have emerged that substantially enhance their therapeutic potential as drug delivery vehicles [77]

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