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Biochem J 1969;112:109-15

Xu et al 83 reported that NEs decreased the P-gp efflux of berberine by 2-fold and increased its permeability by 5.5-fold in vitro Caco-2 cells transport and in situ single-pass intestinal perfusion investigations

The post-stimulation PAC had a significant negative correlation with nocturnal BP dipping rates ( R = 0.387, p = 0.020), whereas pre-stimulation PAC did not ( R = 0.217, p = 0.204)

It should be noted, however, that these observations were made using animal microsomes and thus their relevance to acetaminophen metabolism in humans still needs to be investigated

H., van Gijtenbeek L

EFS ID: 32278349