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In contrast, the normal cells (IBR.3 and HMEC) showed little (HMEC) or no (IBR.3) ALT activation (Fig

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Moreover, LMP can occur downstream of MLKL recruitment, suggesting that lysosomes participate in execution of necroptosis [142]

Among all the NOXs, DUOX and NOX-4 primarily generate H 2 O 2 , while the others mainly generate superoxide [18, 19]

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