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Strategies and challenges of CAF-targeted therapy Although some therapeutic strategies have shown promising results in preclinical studies, particularly in enhancing anti-cancer immune responses mediated by IFN- and TNF-, and promoting CD8 + T cell cytotoxicity, CAF-targeted therapies still face several challenges, especially in improving the specificity of treatment and reducing systemic side effects

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doi: 10.1089/ars.2011.3923

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