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It is also essential for folate and related one-carbon metabolism, where FAD is required as a cofactor for methylenetetrahydrofolate reductase (MTHFR), a key folate-metabolizing enzyme

in Surface Modification of Nanoparticles for Targeted Drug Delivery (ed Pathak, Y.V.) 3371 (Springer International Publishing, 2019)

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Another prospective observational study by Dal Canto et al
