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L-carnitine and acylcarnitines are established mitochondrial biomarkers used to screen neonates for a series of genetic disorders affecting fatty acid oxidation, known as the inborn errors of metabolism

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This variation is strongly associated with reduced or altered MC1R receptor function, which can impair the ability of melanocytes to respond effectively to melanocortin signaling from -MSH or peptide analogs such as Melanotan-1

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