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Description

Inhibitors of SLC7A11 suppress cystine uptake, leading to a depletion of GSH and resulting in cell death mechanisms such as apoptosis and ferroptosis [200, 201]

Name Dihexa Synonyms amide Dihexa PNB-0408 aminohexanoic Dihexa (PNB-0408) N-hexanoic-Tyr-Ile-(6) Hexanoyl-Tyr-Ile-Ahx-NH2 TIANFUCHEM--1401708-83-5---Dihexa N-hexanoic-Try-Ile-(6)-amino hexanoic amide N-(1-OXOHEXYL)-L-TYROSYL-N-(6-AMINO-6-OXOHEXYL)-L-ISOLEUCINAMIDE L-Isoleucinamide, N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)- CAS 1401708-83-5 EINECS 227-005-2

The isoenzyme Glutathione S-Transferase Pi 1 (GSTP1) can promote brain detoxification and cell protection by modifying the effect of neurotoxins and OS products (70)

IV nutrition increases the bio-availability of these nutrients as well as temporarily boosts metabolic activity at the cellular level so energy is manufactured at a higher rate and is more efficient

Since the GSH depleted mutants were sensitive to Fe deficiency, the next pertinent point was to identify the Fe transporters that might be regulated by GSH