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anoszka, K

The four-week hold per step is not arbitrary it matches the interval at which GI adverse events subside as the gut adapts

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As a non-selective antagonist of adenosine receptors (primarily A1 and A2A), caffeine modulates neuronal excitability, synaptic transmission, and neuroinflammatory signaling, all of which are perturbed after ischemic injury (165)

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In patients who are nil by mouth or require temporary enteral access, parenteral neostigmine may be used as a short-term bridge
