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Class I mutants due to nonsense mutations can potentially be corrected by aminoglycoside antibiotics by decreasing the codon-anticodon fidelity, resulting in read-through of the premature stop codon

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Annu Rev Pharmacol Toxicol 38:289319 Kumar KG, Sutton GM, Dong JZ, Roubert P, Plas P, Halem HA, Culler MD, Yang H, Dixit VD, Butler AA (2009) Analysis of the therapeutic functions of novel melanocortin receptor agonists in Mc3r- and Mc4r-deficient C57bl/6j mice