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Early Cellular Activation*

GHK-Cu promotes fibroblast proliferation, collagen synthesis, angiogenesis, and ECM remodeling, while KPV, including advanced formulations such as KPV@PPP_E, exerts anti-inflammatory effects and supports tissue repair

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Israel et al., 2017) showed that female mice were more susceptible than males to develop an ethanol-induced neuroinflammation

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Consequently, strong CYP3A4 inhibitors (e.g., certain azole antifungals, macrolides) or inducers (e.g., carbamazepine, rifampicin, chronic smoking) may further shift the effective metabolic phenotype and plasma exposure, particularly in patients who are already genetically predisposed to reduced or increased metabolic capacity (Wang et al., 2022)