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As a result, recent strategies have been shifted toward developing non-invasive drug delivery methods to improve brain drug delivery, including the use of prodrugs, nanoparticles, focused ultrasound, and intranasal (IN) delivery methods (Terstappen et al., 2021)
Thats the type of B12 that can actually be delivered, get in the cells, and do what its supposed to do
Unlike older peptides in its class, it is selective, meaning it does not spike cortisol, prolactin, or hunger hormones in the way some earlier compounds did
Additionally, novel compounds such as the SERMs/SERDs hybrid bazedoxifene and the selective ER covalent antagonists are undergoing phase 2 clinical trials for patients experiencing disease progression following advanced endocrine therapy
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