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Tirzepatide, a dual GIP/GLP-1 agonist, showed up to 20.9% average weight loss in SURMOUNT-1 at 72 weeks

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widely cited timeframes such as 28 days are unverified and should not be treated as clinical guidance

A 56 percentage point difference is real and clinically meaningful at scale especially for patients with severe obesity who need maximum weight loss

Beyond appetite control and weight loss, GLP-1s may also support heart, kidney, liver, and brain healthand potentially even reduce addictive behaviors

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