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The objectives were to: Provide superior intracellular absorption Create a heat-stable product that does not require refrigeration

This may also increase cocaine's cardiotoxicity
Other adjustment methods less affected by inter-individual variability introduced by muscle mass, diet, health and physical activity, like specific gravity or osmolality, are preferred to adjust for urinary dilutions in observational studies targeting a population

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For someone with obesity, the cardiovascular risk reduction from losing 25% of their body weight almost certainly exceeds the risk from a 5 to 10 beat per minute resting heart rate increase
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