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Plumbagin ameliorates ferroptosis of ovarian granulosa cells in polycystic ovary syndrome by down-regulating SLC7A5 m6A methylation modification through inhibition of YTHDF1

doi: 10.3390/ijms20174289

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The integrated analysis of the experimental X-ray crystallography data herein presented with computational analysis and literature data on homologous enzymes strongly supports the identification of at least two druggable sites on SmTGR, i.e., sites S3 (doorstop) and S8, the later described for the first time here