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18,19 Besides using LCMS to quantify SAH, detection methods for the SAH are generally indirect and applicable for all SAM-dependent methyltransferases

2007;30(1):7983 Singh M, Sharma R, Kumar A

Other symptoms may include: Glossitis (sore, red tongue) Mouth ulcers Visual disturbances (rare, due to optic neuropathy, requiring urgent assessment) Gastrointestinal symptoms such as diarrhoea or constipation It is crucial to recognise that neurological damage from B12 deficiency can become irreversible if left untreated for prolonged periods

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Acyl groups directly bind to copper ions, causing the abnormal aggregation of acylated proteins