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Uncontrolled proliferation associated with oncogene overexpression often exhausts dNTP pools, leading to replication fork stalling, double-strand breaks, and genome instability 15,16

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Both fingolimod doses were superior to placebo regarding MRI-related measures (number of new or enlarged lesions on T2-weighted images, Gd+ lesions, and brain-volume loss

Clin Endocrinol (2010) 72:37782