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It is the core structure for distributing mechanical loads, enabling bending movements, and providing shock absorption in the spine, with its good elasticity and osmotic properties providing flexibility and stability to the spine ( Anatomically, the annulus fibrosus tightly encircles the nucleus pulposus in a lamellar fashion

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The oral bioavailability of berberrubine may surpass that of BBR

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4.9 Alpha-Lipoic Acid In its reduced dihydrolipoate form, alpha-lipoic acid (ALA) reacts with ROS and reactive nitrogen species and protects cell membranes by interfering with the vitamin C and E pathways [124]