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This is due to the possibility that more glycine and serine may be needed to properly catabolize the extra methionine, unintentionally leading to a shortage in these amino acids

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The Architect HCV Ag assay has been suggested as a better monitoring tool in the era of new all-oral, interferon-free antiviral treatments that do not require high analytical sensitivity[62]
Cold Spring Harb Mol Case Stud 2017;3: pii:a001677

Moreover, studies have shown that atherosclerosis usually precedes ischemic heart disease (Panizzi et al., 2010), and that atherosclerosis induces myocardial infarction, which leads to a drastic reduction in myocardial contractility, dilation of the left ventricle, and a significant reduction in the hearts pumping capacity, which can easily lead to heart failure (Swirski and Nahrendorf, 2013)

[DOI] [PMC free article] [PubMed] [Google Scholar] 214.Van Eck M., Zimmermann R., Groot P.H., Zechner R., Van Berkel T.J