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Engagement of NTS Glu8.2 Calcr/Prlh neurons by cagrilintide in rats but not in mice To identify cellular mediators of cagrilintide action, we used expression of the immediate early gene Fos and its downstream target genes (the Fos regulon) as a transcriptional proxy for neuronal activation

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The peptide earned its name from early research demonstrating protective effects across multiple organ systems

Weekly dose 15 mg Average weight loss 22.5% Plain-English read Maximum dose