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10.1016/S0301-0082(00)00017-4 [DOI] [PubMed] [Google Scholar] 170.Pasquin S, Sharma M, Gauchat J-F

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Despite the short plasma half-life, downstream biological effects in tissue persist substantially longer, consistent with a signaling cascade rather than direct dose-response activity

Acknowledgements This work was supported in part by Grants-in-Aid for Scientific Research (B) (grant numbers JP23K24259 and 23K22364 to MK, 21H03806 to TO) and a Grant-in-Aid for Young Scientists (grant number 21K15719 to YYA) from the Japan Society for the Promotion of Science

doi: 10.1007/s12035-020-02034-w 228 LiuZ.WangM.ZhangC.ZhouS.JiG