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These metabolites do not play significant biological roles and are excreted through bile, feces, and urine (151)

10.1016/j.molmed.2023.05.013 110 LiE.YinH.SuM.LiQ.ZhaoY.ZhangL.et al (2023b)

"Current Nanocarrier Strategies Improve Vitamin B12 Pharmacokinetics, Ameliorate Patients' Lives, and Reduce Costs"

Table 6 File drawer analysis
Indeed, loss of GCH1, 6-pyruvoyl-tetrahydropterin synthase or sepiapterin reductase sensitize cancer cells to GPX4 inhibition [53] and overexpression of GCH1 is sufficient to increase resistance to Gpx4 loss and inhibition and imidazole ketone erastin (IKE) treatment [54]

Although no significant increase in GSH or ASA contents was evident after HL exposure of Arabidopsis (Figures 7A and 8A), the proportion of oxidized forms of glutathione (GSSG, HL15) and ascorbate (DHA, HL60) increased in leaves, strongly suggesting that GSH and ASA had been utilized for protection against oxidative stress (Figures 7B and 8B), in accordance with earlier reports (Yoshimura et al., 2000
