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6a, TNF supplementation in the media for 8 h induced robust gene expression levels of both c-FLIP and c-IAP, which were significantly downregulated by a 2-h pretreatment with H 2 O 2 , BCNU, or diamide

This explains the shift from a depolarizing to a hyperpolarizing effect

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Additionally, some researchers believed that the spleen might also be one source of islets, with splenic cells potentially differentiating into insulin-producing cells (100)