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Margaritelis et al

Deficiency of multimeric forms could be related to a proinflammatory environment with abnormal accumulation of apoptotic macrophages and foamy macrophages in lungs and plaques (100, 101, 105)

[DOI] [PubMed] [Google Scholar] 110

antibody-drug conjugates are provided that comprise an anti-ALPP/ALPPL2 antibody attached to a cytotoxic/cytostatic drug, for example a drug that has activity against both dividing and resting tumor cells, such as DNA chelating agents

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Together, these effects contribute to the dual mitigation of lung fibrosis and improved survival in mice
