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Inadequate absorption or utilisation of Vitamin B12 because of age, gastric abnormalities such as Coeliac disease, inflammation of the stomach or intestines, after stomach and bowel surgery, and inflammatory bowel diseases (Crohns disease)

[DOI] [PMC free article] [PubMed] [Google Scholar] Mori Y

L., Naismith, J

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Although not much is known about these enzymes in cancer, the CHAC2 isoform has already been classified as a tumour suppressor gene in gastric and colorectal cancer, on the basis of its downregulation being associated with more aggressive cancer variants and its activation-inducing apoptosis in cancer cells

This is accomplished by activating hematopoietic stem cells by inhibiting suppressor of cytokine signaling 3 (SOCS3) expression and enhancing the IL6/STAT3 pathway (Zhao S