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Also, DNA methylation changes linked to carcinogenesis have been demonstrated 11-13

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for more than a decade, with minimal government oversight or research

They sum up their argument in the following manner: our study suggests that future cigarette tax increases will have relatively few public health benefits, and the justification of future taxes should be based on the public finance aspects of cigarette taxes such as the regressiveness, volatility, and rate of revenue growth associated with those taxes

The real process inside that cigarette is more complicated