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Exposure to Lipopolysaccharide and/or Unconjugated Bilirubin Impair the Integrity and Function of Brain Microvascular Endothelial Cells

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It has been suggested that ALA predominantly ameliorates oxidative stress in the mammalian brain through NRF2 activation (Macias-Barragan et al., 3) and microarray data (Table S4) of mouse brains did not reveal any changes in NFE2L2 mRNA levels and signaling pathway, indicating that the observed ALA effects on gene expression are mediated by another signaling pathway

doi: 10.3389/fonc.2024.1490740 Received 03 September 2024 Accepted 16 December 2024 Published 07 January 2025 Volume 14 - 2024 Edited by Antonella DAnneo, University of Palermo, Italy Reviewed by Jianqiang Xu, Dalian University of Technology, China Zeng Yi, Third Military Medical University, China Updates Copyright 2025 He, Zhang, Peng and He

[DOI] [PubMed] [Google Scholar] 62.Furuta T., Ohshima C