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(2005) investigated the relationship of glutathione and AsA concentrations in the activation of plant innate stress responses through antioxidative metabolism and it was concluded that elevated levels of glutathione, its reduced form, and ascorbate deficiency triggers salicylic acid (SA) mediated signaling that is independent of H 2 O 2

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It is established that glutathione peroxidase-4 (GPX4) deficiency or inhibition enhances the production of endogenous HNE in vivo and in vitro (56-58)

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Furthermore, polymer micelles composed of methoxy-poly(caprolactone)-poly(ethylene glycol) enabled the delayed release of curcumin (218)

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The cell death induced by the B2M-ADC does not seem to be led by apoptosis but rather by necrosis 49

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