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Spry et al 48 demonstrated that chronic topical application of forskolin in MC1R-deficient mice led to epidermal thickening, attributed to the accumulation of nucleated keratinocytes, and increased melanocyte presence

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Multiple elongated densities, possibly sterols or retained lipids, can be seen surrounding M1, M5, and M6, at the interface with M7, and in a hydrophobic pocket at the back of the protein, formed by M1, M5, and M6 (Fig 4D)