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FIGURE 1 ROS produced by heavy metals can induce the ROS by direct or indirect reaction (Paithankar et al., 2021)

This is due to the fact that M1 macrophages, which are pro-inflammatory, possess higher concentrations of inducer nitric oxide synthase (iNOS), leading to a greater production of nitric oxide free radicals and stronger protection against lipid peroxidation, when compared to M2 macrophages, which are anti-inflammatory and have lower iNOS concentrations (83)

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