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Metformin treatment of diabetes causes B12 to accumulate in the liver, thus lowering serum B12 concentrations (Allen et al., 2018)

10.1016/J.SLEEP.2022.09.016 [DOI] [PubMed] [Google Scholar] Chen S, Xie Y, Li Y et al (2022b) Sleep deprivation and recovery sleep affect healthy male residents pain sensitivity and oxidative stress markers: The medial prefrontal cortex may play a role in sleep deprivation model

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Notably, blockade of D 2 receptors in the medial prefrontal cortex has been shown to attenuate cocaine self-administration (Goeders and Smith, 1983)

For comparison, standard testosterone replacement therapy for male hypogonadism typically does not exceed 100 mg per week