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K., Ersek, M., Risler, L., & Shen, D

Early events in the pathogenesis of chronic obstructive pulmonary disease

TGF-1, fibronectin, and VEGF levels are lowered during remodeling, whereas raising collagen-I mRNA levels reduces the expression of ATF-3 and Inos (Kurek-Grecka et al., 2020)

Daily injections of 12mg for rapid correction of significant deficiency, then weekly maintenance

If you are tolerating your current dose well with single weekly injections, there is no compelling reason to switch to split dosing

Conclusions: Exercise in general is a moderately effective treatment option to mitigate pain catastrophizing, although various treatment modalities may prove more practical than others due to their nature