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Animal models confirm TMAOs pathogenic role: reducing plasma TMAO slows CKD progression (138), while TMAO accelerates diabetic nephropathy by activating NLRP3 inflammasome, promoting IL-1/IL-18 release, and worsening renal dysfunction/fibrosis (139)

10.1002/jcb.26398 J

YD: Formal analysis, Investigation, Validation, Writing original draft, Writing review & editing

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This is clearly not the case, as mutants in various aging pathways differentially alter overall fat storage