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Experiments in vitro have demonstrated that mechanical stress triggers [Ca2+]i elevations in retinal ganglion cells, microvascular endothelial cells, nonpigmented cells of the ciliary body, glia and the trabecular meshwork (51, 113, 118-120) whereas Ca2+ removal from the external medium or calcium chelation block stretch- and swelling-induced Ca2+ influx and stretch-induced remodeling of the cytoskeleton

Conversely, enriching the gut microbiota with fiber-fermenting bacteria increases SCFA production and has protective effects: SCFAs signal through receptors like GPR43/GPR109A on immune cells to suppress NF-B activation and induce Tregs [70]

(2019) 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction

& Hall, C

8 , eabh3260 (2022)

Glutathione is sometimes referred to as the "master antioxidant" in the body, with a protective role in the liver, a hardworking organ that needs particular protection from oxidative stress