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Common early signs include: Numbness or reduced ability to feel pain or temperature changes , especially in the feet and toes
& Mller, S
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However, in a meta-analysis which included case-control studies and cohort studies as well as RCTs, plaque size and pain but not curvature were significantly improved using ESWT [77]
doi: 10.1111/j.1749-6632.1964.tb45034.x
Notably, these data pointed out a possible mechanism involving mGluR5 in the regulation of these adipokines
