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C 9 truncated phospholipid aldehydes and derived nonionized carboxyls do not induce membrane curvature, but they do increase permeability toward larger molecules, while those species with C 9 truncated carboxylic acid moieties induce permeabilization and membrane curvature in a pH-dependent manner because of the ionization-dependent exposure of the carboxyl group to the water-bilayer interface

This function is especially important in erythrocytes, which lack mitochondria and therefore depend exclusively on the PPP for cytosolic NADPH

2022;1868(9) doi: 10.1016/j.bbadis.2022.166440

This rise in obesity rates has led to an increase in the search for medical treatments like Tirzepatide

Cryan JF

However, testing this assumption awaits further systematic experiments