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The most useful signal is whats sometimes called the hair of the dog response

Additionally, many currently available LDDS formulations were originally developed as antimicrobial agents, primarily designed to suppress bacterial load rather than directly modulate host immune responses, promote tissue regeneration, or rebalance the microbiome

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doi: 10.1093/carcin/bgg116 [DOI] [PubMed] [Google Scholar] 96.Cairns RA, Harris IS, Mak TW

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MTrPs are classified into two types based on whether they cause spontaneous pain: latent and active