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In vitro study using human vascular endothelial cells further confirmed the increased mRNA and protein expressions of VEGFR2 but not VEGF-A by BPC 157

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Together these results suggest that the vasoconstrictor/vasodilator effects of AVP are dependent on several factors, including the nature or location of the vascular beds, the type of receptor present in the target tissue, and the stress condition (e.g., normoxia/hypoxia)