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Indeed, such abnormal presence of mitochondria in circulating red blood cells causes increased oxygen consumption, ROS generation, and hemolysis in SCD patients 50,51

Phosphatidylserine dynamics in cellular membranes

Verschoor CP, Johnstone J, Millar J, Dorrington MG, Habibagahi M, Lelic A, Loeb M, Bramson JL, Bowdish DM

Trends Endocrinol Metab 25:452463

With such tight metal-protein affinities, off-rates to the hydrated state would be so slow as to exceed the lifetimes of proteins before thermodynamic equilibrium is approached: Associative ligand exchange overcomes this limitation

K.PortugalC.YanC.ZaccaroC.et al (2005)
