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Shah AA, Kamal MA, Akhtar S (2021) Tumor angiogenesis and VEGFR-2: mechanism, pathways and current biological therapeutic interventions

Future research should focus on conducting more detailed preclinical studies to clarify its exact molecular mechanisms in various diseases, particularly in complex conditions like neurodegenerative disorders (e.g., Parkinsons disease) and cancer (Xiong et al., 2024

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However, administration of GH and subsequent GH-mediated effects were found to be dose dependent, as high concentrations given to GH-deprived canines caused atrophy of testes and accessory organs, thinning of prostatic epithelium and a reduction in LH and testosterone levels (75)

Another important disadvantage of cytolytic peptides is their nonspecific cytotoxicity, which was discussed in a study by Zhao et al